I believe in the concept of science and spiritual together make sense always.
Self-realisation is having accurate knowledge of the self and experiencing it. It is all about understanding myself - my true identity, my true nature and form and knowing the goal of life. Everyone in the world have their own identity to differentiate from others and anyone will tell their identity as their Name, Location, Language etc,. These are all some of the attributes, which are used to identify a person.
Believe yourself now as you are only a soul and you are using your body as an instrument. Generally all the part of the body is controlled by your brain, so you(soul) control your body by using your brain. It is important to realize, that we are souls of having our own unique characteristic.
For example:
A driver(Soul) Control only steering/accelerator/break(Brain) which actually control the whole body.
I got this Knowledge through Bhrama Kumaris, Still I have a lot more to say about my understanding about Me and My God and Universe.